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About single domain

Creative Biolabs also has sufficient expertise in constructing synthetic na´ve single domain antibody libraries. By nature, single domain antibodies developed from either VHH or VNAR are more stable and soluble, although their immunogenicity can be higher than single domain antibodies engineered from human antibodies. If the immunogenicity of the single domain antibodies is not a concern, a synthetic VHH or VNAR single domain antibody library can be made by randomizing the CDR1 and CDR3 using trimer codon technology.

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