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About acid base catalysis

In acid-base catalysis, the chemical reaction is accelerated by the addition of an acid or a base, and the acid or base itself is not consumed in the reaction. Proton transfer is the commonest reaction that enzymes perform. Proton donors and acceptors, i.e. acids and base may donate and accept protons in order to stabilize developing charges in the transition state. This typically has the effect of activating nucleophile and electrophile groups, or stabilizing leaving groups. Many acid-base catalysis reactions involve histidine because it has a pKa close to 7, allowing it to act as both an acid and a base.

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